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Descend deeper into the twisted world of The Binding of Isaac with the Four Souls Requiem expansion and Big Boi Treasure Box! This massive expansion nearly doubles your card collection with over 260 new cards, 20 new playable characters, terrifying bosses, and iconic items for even wilder gameplay.&..

This is the Second Edition of The Binding of Isaac: Four Souls. All cards have been updated with enhanced backgrounds and updated wording for clarity.The official Binding of Isaac multiplayer card game is about sacrifice, betrayal and hoarding. 2-4 players take turns playing loot cards and using ite..